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Chemical Structure : Sitravatinib
CAS No.: 1123837-84-2
Catalog No.: PC-45100Not For Human Use, Lab Use Only.
Sitravatinib (MGCD-516) is a broad spectrum small molecule inhibitor that blocks a wide array of RTKs known to be amplified/overexpressed in sarcomas, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl (IC50=1.5-30 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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Sitravatinib (MGCD-516) is a broad spectrum small molecule inhibitor that blocks a wide array of RTKs known to be amplified/overexpressed in sarcomas, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl (IC50=1.5-30 nM).
Sitravatinib (MGCD-516) significantly blocks the phosphorylation of potential driver RTKs and induces potent anti-proliferative effects in vitro.
Sitravatinib (MGCD-516) suppresses tumor growth in tumor xenografts in vivo.
| M.Wt | 629.6763 | |
| Formula | C33H29F2N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)- |
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1. Patwardhan PP, et al. Oncotarget. 2016 Jan 26;7(4):4093-109.
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