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Chemical Structure : Skp2-2
Catalog No.: PC-21056Not For Human Use, Lab Use Only.
Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.
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Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.
Skp2-2 increases the protein levels of p21 and p27, inhibit Skp2 expression up to 90%, in SGC-7901, a gastric cancer cell with high Skp2 expression.
Skp2-2 also influence the mRNA levels of Skp2, p21, and p27, showed significant S-phase arrest, with the proportion of S-phase.
| M.Wt | 298.36 | |
| Formula | C16H14N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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