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Skp2-2

Chemical Structure : Skp2-2

CAS No.: 851164-65-3

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Skp2-2

Catalog No.: PC-21056Not For Human Use, Lab Use Only.

Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.
    Skp2-2 increases the protein levels of p21 and p27, inhibit Skp2 expression up to 90%, in SGC-7901, a gastric cancer cell with high Skp2 expression.
    Skp2-2 also influence the mRNA levels of Skp2, p21, and p27, showed significant S-phase arrest, with the proportion of S-phase.

    Physicochemical Properties

    M.Wt 298.36
    Formula C16H14N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-phenyl-N-(quinolin-8-yl)methanesulfonamide

    References

    1. Hu K, et al. Sci Rep. 2021 Oct 26;11(1):21105.

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