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Chemical Structure : Smoothib
Catalog No.: PC-61149Not For Human Use, Lab Use Only.
Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
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Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
Smoothib inhibits Gli-mediated luciferase expression with IC50 of 1.4 uM in Gli-dependent reporter gene assay.
Smoothib reduces the expression of Hh target genes, and suppresses the growth of Ptch+/- medulloblastoma cells.
| M.Wt | 543.675 | |
| Formula | C33H33N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kremer L, et al. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025.
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