Socrodeucitinib (HS-10374) | TYK2 inhibitor

Chemical Structure : Socrodeucitinib

Socrodeucitinib (HS-10374, HS10374)

Catalog No.: PC-25094Not For Human Use, Lab Use Only.

Socrodeucitinib (HS-10374) is a potent, selective, allosteric oral tyrosine kinase 2 (TYK2) inhibitor, binds to the pseudokinase domain of TYK2 with IC50 of 0.633 nM.

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Biological Activity

Socrodeucitinib (HS-10374) is a potent, selective, allosteric oral tyrosine kinase 2 (TYK2) inhibitor, binds to the pseudokinase domain of TYK2 with IC50 of 0.633 nM.

Socrodeucitinib (HS-10374) shows minimal activity against the catalytic domain of JAK1/2/3 and TYK2, with the IC50 of 5952, 4505, 2567 and >10,000 nM, respectively.

Socrodeucitinib (HS-10374) inhibits subsequent TYK2 downstream signalling pathway events.

Socrodeucitinib (HS-10374) selectively inhibits TYK2 cytokine signalling pathways in psoriasis pathogenesis.

Physicochemical Properties

M.Wt	451.51
Formula	C22H21D3N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridazinecarboxamide, 6-[(cyclopropylcarbonyl)amino]-4-[[3-(1-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-methoxyphenyl]amino]-N-(methyl-d3)-

References

1. Patent CN113968846 A 2022-01-25. 2. Han L, et al. J Eur Acad Dermatol Venereol. 2026 Jul 28. doi: 10.1111/jdv.70643.

Socrodeucitinib (HS-10374, HS10374)

Biological Activity

Physicochemical Properties

References

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