Soficitinib (ICP-332) | TYK2 inhibitor

Chemical Structure : Soficitinib

CAS No.: 2574524-67-5

Soficitinib (ICP-332, ICP332)

Catalog No.: PC-25095Not For Human Use, Lab Use Only.

Soficitinib (ICP-332) is a potent, selective second-generation tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the ATP-binding site of the TYK2 JH1 domain over the highly homologous catalytic domains of other JAK family members.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Biological Activity

Soficitinib (ICP-332) is a potent, selective second-generation tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the ATP-binding site of the TYK2 JH1 domain over the highly homologous catalytic domains of other JAK family members.

Physicochemical Properties

M.Wt	400.87
Formula	C18H21ClN8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3aS,6aR)-5-(5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3a-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-oxopropanenitrile

References

1. Patent WO2020259584 A1.

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Soficitinib (ICP-332, ICP332)

Biological Activity

Physicochemical Properties

References

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