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Sortin1

Chemical Structure : Sortin1

CAS No.: 503837-98-7

Sortin1 (Sortin-1)

Catalog No.: PC-43236Not For Human Use, Lab Use Only.

Sortin1 is a small molecule sorting inhibitor (Sortin) that induces reversible defects in vacuole biogenesis and root development in Arabidopsis seedlings at 100 mg/liter (227 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Sortin1 is a small molecule sorting inhibitor (Sortin) that induces reversible defects in vacuole biogenesis and root development in Arabidopsis seedlings at 100 mg/liter (227 uM); induces secretion of the AtCPY (carboxypeptidase Y) precursor in Arabidopsis cell suspensions; Sortin1 is a powerful chemical to control the induced phenotype in a manner that would be difficult to achieve using conventional genetics.

Physicochemical Properties

M.Wt 441.4322
Formula C26H19NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Indeno[1,2-b]pyridine-3-carboxylic acid, 4-[5-(4-carboxyphenyl)-2-furanyl]-4,5-dihydro-2-methyl-5-oxo-, 3-methyl ester

References

1. Zouhar J, et al. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501.

2. Rosado A, et al. Chem Biol. 2011 Feb 25;18(2):187-97.

3. Komatsu R, et al. Bioorg Med Chem Lett. 2018 Mar 23. pii: S0960-894X(18)30255-5.

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