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Stibogluconate sodium

Chemical Structure : Stibogluconate sodium

CAS No.: 16037-91-5

Stibogluconate sodium (Sodium stibogluconate)

Catalog No.: PC-42207Not For Human Use, Lab Use Only.

Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer activity in synergy with IFNs.

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Biological Activity

Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer activity in synergy with IFNs.

Physicochemical Properties

M.Wt 910.9
Formula C12H38O26Sb2Na3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 550 mg/mL (Need warming); DMSO: < 9.1 mg/mL

Chemical Name/SMILES

D-Gluconic acid, 2,4:2',4'-O-(oxydistibylidyne)bis-, sodium salt, hydrate (1:3:9)

References

1. Berman JD, et al. Antimicrob Agents Chemother. 1985 Jun;27(6):916-20.

2. Fan K, et al. J Immunol. 2010 Jun 1;184(11):6529-36.

3. Pathak MK, et al. J Immunol. 2001 Sep 15;167(6):3391-7.

4. Yi T, et al. J Immunol. 2002 Nov 15;169(10):5978-85.

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