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Chemical Structure : Succinyl phosphonate
CAS No.: 26647-82-5
Catalog No.: PC-43150Not For Human Use, Lab Use Only.
Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $85 | In stock | |
| 25 mg | $225 | In stock | |
| 100 mg | $385 | In stock | |
| 250 mg | Get quote |
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Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation; inhibits both muscle and bacterial α-ketoglutarate dehydrogenase complexes (KGDHC), as well as muscle alpha-ketoglutarate dehydrogenase; inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ; impairs viability of cancer cells in a cell-specific metabolism-dependent manner.
| M.Wt | 182.0685 | |
| Formula | C4H7O6P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Butanoic acid, 4-oxo-4-phosphono- |
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1. Biryukov AI, et al. FEBS Lett. 1996 Mar 11;382(1-2):167-70.
2. Bunik VI, et al. Biochemistry. 2005 Aug 9;44(31):10552-61.
3. Zündorf G, et al. Neuroscience. 2009 Jan 23;158(2):610-6.
4. Bunik VI, et al. Oncotarget. 2016 May 3;7(18):26400-21.
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