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Chemical Structure : Sufugolix
CAS No.: 308831-61-0
Catalog No.: PC-42085Not For Human Use, Lab Use Only.
A highly potent and orally bioavailable non-peptide antagonist of luteinizing hormone-releasing hormone (LHRH) receptor with binding and functional IC50 of 0.1 and 0.06 nM for human LHRH, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $256 | In stock | |
| 50 mg | $432 | In stock | |
| 100 mg | $752 | In stock |
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Sufugolix (TAK-013) is a highly potent and orally bioavailable non-peptide antagonist of luteinizing hormone-releasing hormone (LHRH) receptor with binding and functional IC50 of 0.1 and 0.06 nM for human LHRH, respectively; completely suppresses plasma LH levels in castrated male cynomolgus monkeys at 30 mg/kg dose with sufficient duration of action (>24 h)
Other Indication
Phase 2 Discontinued
| M.Wt | 667.7242 | |
| Formula | C36H31F2N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy- |
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1. Sasaki S, et al. J Med Chem. 2003 Jan 2;46(1):113-24.
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