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Chemical Structure : Sulfopin
CAS No.: 2451481-08-4
Catalog No.: PC-22076Not For Human Use, Lab Use Only.
Sulfopin is a potent, selective and covalent inhibitor of Pin1 with Ki of 17 nM in FP assay, targets Pin1's active site Cys113, blocks Myc-driven tumors.
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|---|---|---|---|
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| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
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Sulfopin is a potent, selective and covalent inhibitor of Pin1 with Ki of 17 nM in FP assay, targets Pin1's active site Cys113, blocks Myc-driven tumors.
Sulfopin inhibits the catalytic activity of Pin1 with an apparent Ki of 211 nM in chymotrypsin-coupled peptidyl-prolyl isomerization assay.
Sulfopin is highly selective for Pin1 Cys113 over other 161 cysteine residues.
Sulfopin could phenocopy Pin1 knockout.
Sulfopin significantly resensitized HeLa cells to irradiation in a dose-dependent manner, and decreases IRAK1 Thr209 phosphorylation at concentrations as low as 100 nM.
Sulfopin (1 μM) shows a Pin1-dependent viability effect following long-term exposure.
Sulfopin downregulates Myc transcriptional activity and increases c-Myc protein levels in Mino B cells, blocks neuroblastoma in zebrafish.
Sulfopin (20 or 40 mg/kg) inhibits pancreatic cancer progression in mice, significantly extends survival.
| M.Wt | 281.80 | |
| Formula | C11H20ClNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide |
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1. Dubiella C, et al. Nat Chem Biol. 2021 Sep;17(9):954-963.
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