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Chemical Structure : Sulfotransferase-IN-1
Catalog No.: PC-60170Not For Human Use, Lab Use Only.
The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM .
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The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth.
| M.Wt | 442.09 | |
| Formula | C17H11BrCl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheung ST, et al. ACS Chem Biol. 2017 Dec 15;12(12):3126-3133.
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