Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Sunvozertinib
CAS No.: 2370013-49-1
Catalog No.: PC-38101Not For Human Use, Lab Use Only.
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | $1380 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM).
DZD9008 downregulates pEGFR with IC50 ranging from 1 to 22 nM in a panel of tumor cell lines expressing EGFR L858R, Exon19del, L858R/T790M, various Exon20ins or uncommon mutations.
DZD9008 shows similary potency against pHER2 in tumor cells with HER2 Exon20ins mutation, with IC50 of 7 nM.
DZD9008 is less potent in modulating pEGFR in tumor cells expressing wild type EGFR (IC50>80 nM).
DZD9008 suppressed cell proliferation with GI50 of 1 to 60 nM in tumor cells carrying EGFR L858R, Exon19del, L858R/T790M, various Exon20ins or uncommon mutations in cell proliferation assays.
DZD9008 exhibits tumor growth inhibition and regression in CDX and PDX models carrying EGFR Exon19del single mutation, L858R/T790M double mutations, and PDX models harboring G719S/L861Q or Exon20ins.
| M.Wt | 584.093 | |
| Formula | C29H35ClFN7O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-N-(5-((4-((5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide |
|
1. Yan Xu, et al. AACR Abstract 3081, Cancer Res (2019) 79 (13_Supplement): 3081.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
