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Chemical Structure : Surfen hydrate
Catalog No.: PC-62073Not For Human Use, Lab Use Only.
Surfen hydrate is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.
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Surfen hydrate is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs; neutralizes the ability of the various heparins to activate antithrombin and inactivate Factor Xa; blocks sulfation and degradation of GAG chains in vitro and alters cellular responses dependent on HS such as growth factor binding and activation, cell attachment, viral infection by HSV, and angiogenesis; also can blocks C5a receptor binding and lethal factor produced by anthrax.
| M.Wt | 445.348 | |
| Formula | C21H22Cl2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schuksz M, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.
2. Lanza TJ, et al. J Med Chem. 1992 Jan 24;35(2):252-8.
3. Panchal RG, et al. Nat Struct Mol Biol. 2004 Jan;11(1):67-72.
4. Roan NR, et al, J Biol Chem. 2010 Jan 15;285(3):1861-9.
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