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Chemical Structure : T-3364366
CAS No.: 1356354-09-0
Catalog No.: PC-61037Not For Human Use, Lab Use Only.
T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.
T-3364366 potently inhibits arachidonic acid (AA) production in liver cell lines derived from human (HepG2) and rat (RLN-10) with IC50 of 1.9 and 2.1 nM, respectively.
T-3364366 exhibits a reversible, slow-binding interaction to the desaturase domain of D5D.
| M.Wt | 443.459 | |
| Formula | C18H16F3N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide |
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1. Miyahisa I, et al. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.
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