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Chemical Structure : T-3764518
Catalog No.: PC-60369Not For Human Use, Lab Use Only.
T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1.
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T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1; induces phosphorylation and activation of AMPK in HCT-116 cells, which led to blockade of downstream fatty acid synthesis and acceleration of autophagy; shows significant pharmacodynamic marker reduction (at 0.3mg/kg, bid) in HCT116 mouse xenograft model and tumor growth suppression (at 1mg/kg, bid) in 786-O mouse xenograft model; exhibits an excellent PK profile.
| M.Wt | 473.379 | |
| Formula | C20H17F6N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Imamura K, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3768-3779.
2. Nishizawa S, et al. Eur J Pharmacol. 2017 Jul 15;807:21-31.
3. Ono A, et al. PLoS One. 2017 Jul 13;12(7):e0181243.
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