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Chemical Structure : T-3861174
Catalog No.: PC-63354Not For Human Use, Lab Use Only.
T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM.
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T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM; induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway; exhibits significant tumor growth inhibition in SK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses.
| M.Wt | 472.524 | |
| Formula | C26H25FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654.
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