Catalog No.: PC-20550Not For Human Use, Lab Use Only.
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 stimulates the mitochondrial translocation of Parkin in a PINK1-dependent manner.
T0467 reduces unfolded mitochondrial protein levels, presumably through enhanced PINK1-Parkin signaling.
T0467 mitigates the locomotion defect, reduced ATP production, and disturbed mitochondrial Ca2+ response in the muscles along with the mitochondrial aggregation in dopaminergic neurons through reduced PINK1 activity in Drosophila.
