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Chemical Structure : T0467
Catalog No.: PC-20550Not For Human Use, Lab Use Only.
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
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T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 stimulates the mitochondrial translocation of Parkin in a PINK1-dependent manner.
T0467 reduces unfolded mitochondrial protein levels, presumably through enhanced PINK1-Parkin signaling.
T0467 mitigates the locomotion defect, reduced ATP production, and disturbed mitochondrial Ca2+ response in the muscles along with the mitochondrial aggregation in dopaminergic neurons through reduced PINK1 activity in Drosophila.
| M.Wt | 441.50 | |
| Formula | C24H26F3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shiba-Fukushima K, et al. iScience. 2020 May 22;23(5):101048.
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