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Chemical Structure : T0901317
CAS No.: 293754-55-9
Catalog No.: PC-42684Not For Human Use, Lab Use Only.
T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | Get quote |
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T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).
T0901317 (TO901317) upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.
T0901317 (TO901317) decreases amyloid-β production in primary neurons in vitro.
T0901317 (TO901317) displays an EC50 of ~ 5 μM for activation of FXRs.
T0901317 (TO901317) also is an inverse agonist of human constitutive androstane receptor (hCAR), blocks the interaction of hCAR with steroid receptor co-activator 1 (SRC1).
| M.Wt | 481.3327 | |
| Formula | C17H12F9NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- |
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1. Repa JJ, et al. Science. 2000 Sep 1;289(5484):1524-9.
2. Koldamova RP, et al. J Biol Chem. 2005 Feb 11;280(6):4079-88.
3. Kanno Y, et al. J Toxicol Sci. 2013;38(3):309-15.
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