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Chemical Structure : T247
Catalog No.: PC-60827Not For Human Use, Lab Use Only.
T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
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T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
T247 induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells.
T247 shows promising activity for anticancer and antiviral benefits.
T247 also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.
| M.Wt | 389.477 | |
| Formula | C21H19N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.
2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.
3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
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