Chemical Structure : TAK-441
CAS No.:
1186231-83-3
TAK-441
(TAK 441;TAK441)
Catalog No. : PC-60477Not For Human Use, Lab Use Only.
TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6047701
Biological Activity
TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
Physicochemical Properties
M.Wt
576.56
Formula
C28H31F3N4O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
References
1. Ohashi T, et al. Bioorg Med Chem
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