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Chemical Structure : TAK-441
CAS No.: 1186231-83-3
Catalog No.: PC-60477Not For Human Use, Lab Use Only.
A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
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A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays; suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model.
Solid Tumors
Phase 1 Discontinued
| M.Wt | 576.56 | |
| Formula | C28H31F3N4O6 | |
| CAS No. | 1186231-83-3 | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name |
6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide |
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1. Ohashi T, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17.
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