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Chemical Structure : TAOK inhibitor 43
Catalog No.: PC-62730Not For Human Use, Lab Use Only.
TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.
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TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.
TAOK inhibitor 43 increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles.
TAOK inhibitor 43 induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.
| M.Wt | ||
| Formula | C25H24N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.
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