| Cat. No. |
Product Name |
Information |
| PC-24647 |
MAP3K1 inhibitor 51-106
MAP3K1 inhibitor
|
MAP3K1 inhibitor 51-106 is a selective MAP3K1 inhibitor with IC50 of 1.8 uM in in MAP3K1 WT cells, binds to MAP3K1 and blocks IKKβ phosphorylation, resulting in the inhibition of TNF-α-induced NF-κB activation. |
| PC-20983 |
IACS-52825
DLK inhibitor
|
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays. |
| PC-49571 |
DLK-LZK inhibitor 64
DLK/LZK inhibitor
|
DLK-LZK inhibitor 64 (example 64) is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK) inhibitor with IC50 of 2 nM and 10 nM, respectively. |
| PC-49564 |
DN-1289
DLK/LZK inhibitor
|
DN-1289 (DN1289) is a potent, selective and CNS-penetrant dual inhibitor of leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK, MAP3K13) with IC50 of 17 nM and 40 nM, respectively. |
| PC-38656 |
ASK1 inhibitor 32
ASK1 inhibitor
|
ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 inhibitor with cellular IC50 of 25 nM. |
| PC-38626 |
IKAM-1
MAP3K1 inhibitor
|
IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM. |
| PC-38374 |
Tilpisertib
Tpl2/MAP3K8 inhibitor
|
Tilpisertib (GS-4875) is a potent, highly selective TPL2 kinase (COT, MAP3K8) inhibitor with IC50 of 1.3 nM, with no significant off-target binding activity. |
| PC-72890 |
GDC-0134
DLK inhibitor
|
GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12). |
| PC-35427 |
GS-444217
ASK1 inhibitor
|
GS-444217 (GS444217) is a potent, selective, ATP-competitive, orally available inhibitor of ASK1 with Kd/IC50 of 4.1/2.87 nM. |
| PC-35394 |
TC ASK10
ASK1 inhibitor
|
TC ASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. |
| PC-43286 |
GNE-3511
DLK inhibitor, LZK inhibitor
|
GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3. |
| PC-62818 |
TAOK inhibitor 63
TAOK inhibitor
|
TAOK inhibitor 63 (TAOK-IN-2) is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively. |
