TAS-103 | Topoisomerase inhibitor | Probechem Biochemicals

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Chemical Structure : TAS-103

TAS-103 (BMS-247615, TAS103)

Catalog No.: PC-25319Not For Human Use, Lab Use Only.

TAS-103 (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	333.39
Formula	C20H19N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one

References

1. Aoyagi Y, et al. Jpn J Cancer Res. 1999 May;90(5):578-87.

2. Utsugi T, et al. Jpn J Cancer Res. 1997 Oct;88(10):992-1002.

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TAS-103 (BMS-247615, TAS103)

Biological Activity

Physicochemical Properties

References

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