Chemical Structure : TAS-103 dihydrochloride
CAS No.: 174634-09-4
Catalog No.: PC-25320Not For Human Use, Lab Use Only.
TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively.
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TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively.
M.Wt | 406.31 | |
Formula | C20H21Cl2N3O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride |
1. Aoyagi Y, et al. Jpn J Cancer Res. 1999 May;90(5):578-87.
2. Utsugi T, et al. Jpn J Cancer Res. 1997 Oct;88(10):992-1002.
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