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Chemical Structure : TAS2940
Catalog No.: PC-49395Not For Human Use, Lab Use Only.
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor.
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TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor.
TAS2940 selectively inhibits phosphorylation of targets and the growth of cancer cells with ERBB aberrations in vitro.
TAS2940 is highly potent against cells harboring HER2/EGFR alteration.
TAS2940 also inhibited tumor growth in xenograft mouse models with ERBB aberrations: HER2 amplification, HER2/EGFR exon 20 insertions, and EGFR vIII mutation.
TAS2940 was effective in the intracranial xenograft models of HER2/EGFR cancers and improved the survival of mice models.
| M.Wt | 482.588 | |
| Formula | C28H30N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kei Oguchi, et al. Cancer Sci. 2022 Oct 25. doi: 10.1111/cas.15617.
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