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Chemical Structure : TASIN-1
CAS No.: 792927-06-1
Catalog No.: PC-72962Not For Human Use, Lab Use Only.
TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
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TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50 = 70 nM) but not toward HCT116 cells (IC50 > 50 μM).
TASIN-1 decreased the endogenous cholesterol biosynthesis rate in APC-truncated HT29 and DLD1 cells but not in APC WT HCT116 and RKO cells, TASIN-1 exerts its cytotoxicity through inhibition of cholesterol biosynthesis.
TASIN-1 inhibits emopamil-binding protein (EBP) or 24-dehydrocholesterol reductase (DHCR24).
| M.Wt | 352.493 | |
| Formula | C18H28N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1'-((4-methoxyphenyl)sulfonyl)-4-methyl-1,4'-bipiperidine |
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1. Zhang L, et al. Sci Transl Med. 2016 Oct 19;8(361):361ra140.
2. Zhang L, et al. Mol Cancer Ther. 2018 May;17(5):943-951.
3. Wang W, et al. J Med Chem. 2019 May 23;62(10):5217-5241.
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