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Chemical Structure : TASK inhibitor F3
Catalog No.: PC-49468Not For Human Use, Lab Use Only.
TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1).
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TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1).
TASK inhibitor F3 displays a reduced inhibition of TASK-3 channels and not a significant effect on different K+ channels.
TASK inhibitor F3 blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells.
Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels.
| M.Wt | 344.414 | |
| Formula | C22H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bárbara Arévalo, et al. J. Med. Chem. 2022.
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