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TAT-QFNP12

Chemical Structure : TAT-QFNP12

CAS No.:

TAT-QFNP12

Catalog No.: PC-27322Not For Human Use, Lab Use Only.

TAT-QFNP12 is a peptide inhibitor of N-myc downstream-regulated gene 2 (NDRG2)-PPM1A interaction, blocks NDRG2-PPM1A binding and reduces Smad2/3 dephosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TAT-QFNP12 is a peptide inhibitor of N-myc downstream-regulated gene 2 (NDRG2)-PPM1A interaction, blocks NDRG2-PPM1A binding and reduces Smad2/3 dephosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH).

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

AA Sequence: YGRKKRRQRRR-VKKEAELDKYLE

References

1. Dayun Feng, et al. Sci Adv. 2022 Sep 30;8(39):eabq2423.

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