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Chemical Structure : TB-03
Catalog No.: PC-61262Not For Human Use, Lab Use Only.
TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).
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TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).
TB-03 does not not affect apoptosis alone, enhances imatinib-induced apoptosis and cell cycle suppression, induction of apoptosi.
TB-03 reduced protein tyrosyl phosphorylation and Grb2 recruitment, suppression of a progenitor/stem cell subpopulation and increased expression of relevant tumor suppressor microRNAs.
| M.Wt | 708.749 | |
| Formula | C36H45N4O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang M, et al. Leukemia. 2014 Apr;28(4):948-51.
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