TBC1D2 inhibitor G2

Chemical Structure : TBC1D2 inhibitor G2

Catalog No.: PC-27253Not For Human Use, Lab Use Only.

TBC1D2 inhibitor G2 is a small molecule TBC1 domain family member 2 (TBC1D2) inhibitor with SPR KD of 0.4 uM, and IC50 of 80 nM in HCCLM3 cells, induces selective autophagic cell death.

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Biological Activity

TBC1D2 inhibitor G2 is a small molecule TBC1 domain family member 2 (TBC1D2) inhibitor with SPR KD of 0.4 uM, and IC50 of 80 nM in HCCLM3 cells, induces selective autophagic cell death.

Physicochemical Properties

M.Wt	590.81
Formula	C38H46N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(41S,7aS,13aR,13bR,E)-11-((6-((4-(piperazin-1-ylmethyl)benzyl)oxy)naphthalen-2-yl)methylene)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one

References

1. Han K, et al. Eur J Med Chem. 2026 Jul 4;317:119124.

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