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Chemical Structure : TC-2153
Catalog No.: PC-62801Not For Human Use, Lab Use Only.
TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM.
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TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM.
TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures.
TC-2153 shows specificity towards STEP compared to several other tyrosine phosphatases.
TC-2153 improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.
| M.Wt | 355.869 | |
| Formula | C7H5ClF3NS5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78.
2. Xu J, et al. PLoS Biol. 2014 Aug 5;12(8):e1001923.
3. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6.
4. Chatterjee M, et al. Neuropharmacology. 2018 Jan;128:43-53.
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