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Chemical Structure : TCS401
CAS No.: 243966-09-8
Catalog No.: PC-42970Not For Human Use, Lab Use Only.
TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.
TCS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA.
TCS-401 reduces RPTC-Sup-induced EGFR dephosphorylation and reverses the levels of fibronectin and α-SMA in renal fibroblasts.
| M.Wt | 306.7227 | |
| Formula | C10H11ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11 mg/mL |
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| Chemical Name/SMILES |
Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, hydrochloride (1:1) |
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1. Iversen LF, et al. J Biol Chem. 2000 Apr 7;275(14):10300-7.
2. Ponnusamy M, et al. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709.
3. Du ZD, et al. Mol Vis. 2015 May 1;21:523-31. eCollection 2015.
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