Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TD-1473
Catalog No.: PC-72341Not For Human Use, Lab Use Only.
TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2.
TD-1473 inhibited cytokine-induced phosphorylation of STAT1 in mouse primary colonic epithelial cells with pIC50 values for inhibition against IL-6, IFNα and IFNγ were 7.3, 6.8 and 7.0.
TD-1473 demonstrated JAK inhibitory activity in ex vivo mouse colon and human IBD patient colonic tissue.
TD-1473 (Izencitinib) is under development for the treatment of ulcerative colitis.
| M.Wt | 402.506 | |
| Formula | C22H26N8 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. Sandborn WJ, et al. J Crohns Colitis. 2020 Sep 16;14(9):1202-1213.
2. Hardwick RN, et al. Toxicol Sci. 2022 Feb 4:kfac002.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
