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Chemical Structure : TDP-665759
Catalog No.: PC-60439Not For Human Use, Lab Use Only.
TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.
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TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.
TDP-665759 inhibits the proliferation of wt p53-expressing cell lines with average IC50 of 0.7 uM, stabilizes p53 protein levels, upregulates p53 target genes in a DNA damage-independent manner, and induces apoptosis in HepG2 cells.
TDP-665759 increases p21(waf1/cip1) levels in mice liver samples, synergizes the effect of doxorubicin both in culture and in an A375 xenograft model.
| M.Wt | 706.45 | |
| Formula | C31H34Cl2IN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Koblish HK, et al. Mol Cancer Ther. 2006 Jan;5(1):160-9.
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