Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TDRL-551
CAS No.: 1644626-43-6
Catalog No.: PC-20337Not For Human Use, Lab Use Only.
TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.
TDRL-551 exhibits single agent anti-cancer activity in the A2780 EOC cell line using clonogenic survival assays with IC50 of 25 uM.
TDRL-551 is synergistic with DNA damaging chemotherapeutic agent in platinum sensitive A2780 cell line.
TDRL-551 displays single agent anti-cancer activity and sensitizes NSCLC tumors to platinum based treatment in vivo.
| M.Wt | 591.83 | |
| Formula | C25H23ClIN3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(2-Chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-1H-pyrazole-1-pentanoic acid |
|
1. Mishra AK, et al. Biochem Pharmacol. 2015 Jan 1;93(1):25-33.
2. Gavande NS, et al. ACS Med Chem Lett. 2020 Jan 2;11(6):1118-1124.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
