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Chemical Structure : TET inhibitor C35
CAS No.: 98570-83-3
Catalog No.: PC-72555Not For Human Use, Lab Use Only.
TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $958 | In stock | |
| 100 mg | Get quote |
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TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome.
TET inhibitor C35 is a general TET inhibitor that targets all members of the TET family.
TET inhibitor C35 also suppresses the catalytic activities of TET1 and TET3 with IC50 3.48 uM and 2.31 uM, respectively.
TET inhibitor C35 treatment reduces genome-wide 5hmC level in human and mouse cells.
TET inhibitor C35 promotes somatic cell reprogramming induces the expression of members of the BMP-SMAD-ID axis.
| M.Wt | 498.484 | |
| Formula | C26H26O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenepentanoic acid, beta,3,4-trihydroxy-, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (betaS)- |
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1. Anup Kumar Singh, et al. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3621-3626.
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