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Chemical Structure : TFC-007
Catalog No.: PC-49640Not For Human Use, Lab Use Only.
TFC-007 (TFC007) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 83 nM.
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TFC-007 (TFC007) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 83 nM.
TFC-007 displays negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
TFC-007 (30mg/kg, p.o.) given once before a challenge almost completely suppressed PGD(2) production in the nasal tissue early and late after the challenge.
| M.Wt | 487.56 | |
| Formula | C27H29N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nabe T, et al. Prostaglandins Other Lipid Mediat. 2011 Aug;95(1-4):27-34.
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