Theaflavin 3,3'-digallate (TFDG) | USP25 inhibitor

Chemical Structure : TFDG

CAS No.: 30462-35-2

TFDG (Theaflavin 3,3'-digallate, TF3, TF-3, ZP10)

Catalog No.: PC-28281Not For Human Use, Lab Use Only.

Theaflavin 3,3'-digallate (TF3, TFDG) is a potent Zika virus (ZIKV) protease inhibitor with IC50 of 2.3 uM, directly binds to ZIKVpro with Kd of 8.86 uM, is also a potent selective a potent USP25 inhibitor with IC50 of 33 nM, 8.5-fold selectivity over its paralog USP28.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$358	In stock
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Biological Activity

Theaflavin 3,3'-digallate (TF3, TFDG) is a potent Zika virus (ZIKV) protease inhibitor with IC50 of 2.3 uM, directly binds to ZIKVpro with Kd of 8.86 uM, is also a potent selective a potent USP25 inhibitor with IC50 of 33 nM, 8.5-fold selectivity over its paralog USP28.
Theaflavin 3,3'-digallate (TF3, TFDG) inhibits ZIKV replication.
Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1.
Theaflavin 3,3'-digallate (TF3, TFDG) exhibits potent antioxidant and lipid-regulatory activities.
Theaflavin 3,3'-digallate (TF3, TFDG) also exhibits anti-tumor activity in hepatocellular carcinoma (HCC), inhibits Pin1 PPIase activity with IC50 of 60.33 uM.
Theaflavin 3,3'-digallate (TF3, TFDG) potently suppressed the viability of HepG2, SK-Hep-1 and Huh-7 cells in both dose- and time-dependent manners.

Physicochemical Properties

M.Wt	868.70
Formula	C43H32O20
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,2'R,3R,3'R)-(3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene-1,8-diyl)bis(5,7-dihydroxychromane-2,3-diyl) bis(3,4,5-trihydroxybenzoate)

References

1. Xiangling Cui, et al. Front Pharmacol. 2020 Oct 21;11:514313.

2. Li Z, et al. Eur J Med Chem. 2026 Sep 17;320:119337.

3. Zhao L, et al. Signal Transduct Target Ther. 2026 May 19;11(1):186.

4. Lv S, et al. Biomolecules. 2026 Apr 14;16(4):583.

TFDG (Theaflavin 3,3'-digallate, TF3, TF-3, ZP10)

Biological Activity

Physicochemical Properties

References

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