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Chemical Structure : TG-6304
Catalog No.: PC-72009Not For Human Use, Lab Use Only.
TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.
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TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.
TC-6304 engages DCN3 in cells in a dose-dependent manner but does not affect the neddylation of any of the cullins.
TC-6304 effectively enhances the thermal stability of cellular DCN3 protein in a dose-dependent manner and has no significant effect on the thermal stability of cellular DCN1 protein (10-1000 nM).
| M.Wt | 583.139 | |
| Formula | C31H33ClF2N4OS | |
| Appearance | Solid | |
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