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Chemical Structure : TGN-020
CAS No.: 51987-99-6
Catalog No.: PC-20300Not For Human Use, Lab Use Only.
TGN-020 (TGN020) is a potent, selective aquaporin 4 (AQP4) inhibitor with IC50 of 3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | $558 | In stock | |
| 1 g | Get quote |
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TGN-020 (TGN020) is a potent, selective aquaporin 4 (AQP4) inhibitor with IC50 of 3 uM.
TGN-020 significantly reduced the cortical infarct volume, with no effect on basal ganglia infarct volume.
Pretreatment with TGN-020 significantly reduced the severity of brain edema associated with brain ischemia.
TGN-020 significantly increases regional cerebral blood flow in vivo, TGN-020 can alleviate spinal cord edema, inhibit glial scar formation, and promote axonal regeneration, conferring beneficial effects on recovery in rats.
| M.Wt | 206.22 | |
| Formula | C8H6N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(Nicotinamido)-1,3,4-thiadiazole |
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1. Igarashi H, et al. Neurol Sci. 2011 Feb;32(1):113-6.
2. Huber VJ, et al. Bioorg Med Chem. 2009;17:411–417.
3. Igarashi H, et al. Neuroreport. 2013 Apr 17;24(6):324-8.
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