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TH301

Chemical Structure : TH301

CAS No.: 450338-32-6

TH301 (TH 301)

Catalog No.: PC-49459Not For Human Use, Lab Use Only.

TH301 (TH 301) is a selective small molecule stabilizer of Cryptochrome 2 (CRY2).
KL101 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TH301 (TH 301) is a isoform-selective small molecule stabilizer of Cryptochrome 2 (CRY2).
TH301 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

Physicochemical Properties

M.Wt 485.983
Formula C24H24ClN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-chlorophenyl)-N-(2-(4-methoxyphenyl)-5,5-dioxido-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)cyclopentane-1-carboxamide

References

1. Miller S, et al. Nat Chem Biol. 2020 Jun;16(6):676-685.

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