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Chemical Structure : TH7299
Catalog No.: PC-47090Not For Human Use, Lab Use Only.
TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.
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TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.
TH7299 is a highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).
TH7299 is a potent inhibitor of the structurally related MTHFD2 isoforms MTHFD2L (IC50: 126 nM) and MTHFD1-DC (IC50: 89 nM).
| M.Wt | 433.381 | |
| Formula | C17H19N7O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.
2. Benramdane S, et al. ChemMedChem. 2022 Jun 27:e202200097.
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