THTZO4a

Chemical Structure : THTZO4a

Catalog No.: PC-28363Not For Human Use, Lab Use Only.

THTZO4a is a potent nonclassical radical-trapping antioxidant and ferroptosis inhibitor with EC50 of 92 nM, effectively suppresses erastin-induced ferroptosis in HT22 cells, as well as RSL3-induced ferroptosis in HSC-LX2, and MIA PaCa-2 cells.

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Biological Activity

THTZO4a is a potent nonclassical radical-trapping antioxidant and ferroptosis inhibitor with EC50 of 92 nM, effectively suppresses erastin-induced ferroptosis in HT22 cells, as well as RSL3-induced ferroptosis in HSC-LX2, and MIA PaCa-2 cells.

Physicochemical Properties

M.Wt	262.36
Formula	C14H22N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-diisopropyl-6-phenyl-1,2,4,5-tetrazinan-3-one

References

1. Ouyang C, et al. Sci Adv. 2026 Feb 27;12(9):eaec2190.

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THTZO4a

Biological Activity

Physicochemical Properties

References

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