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Chemical Structure : TJ-M2010-5
CAS No.: 1357471-57-8
Catalog No.: PC-38670Not For Human Use, Lab Use Only.
TJ-M2010-5 is a small molecule MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 100 mg | $548 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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TJ-M2010-5 is a small molecule MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway.
TJ-M2010-5 inhibited MyD88 homodimerization in transfected HEK293 cells in a concentration-dependent manner and suppressed MyD88 signaling in LPS-responsive RAW 264.7 cells in vitro.
TJ-M2010-5 decreased cell proliferation, and increased apoptosis in colon tissue, also inhibited production of inflammatory cytokines and chemokines (TNF-α, IL-6,G-CSF, MIP-1β, TGF-β1, IL-11, IL-17A, IL-22 and IL-23) and infiltration of immune cells (macrophages, dendritic cells, neutropihls and CD + 4 T cells) in colon tissues of mice.
| M.Wt | 406.55 | |
| Formula | C23H26N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl)) propanamide |
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1. Xie L, et al. J Natl Cancer Inst. 2015 Dec 28;108(4):djv364.
2. Liu JH, et al. Exp Cell Res. 2020 Sep 15;394(2):112157.
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