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Chemical Structure : TK216
CAS No.: 1903783-48-1
Catalog No.: PC-61994Not For Human Use, Lab Use Only.
TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma.
TK216 acts as an microtubule destabilizing agent, exhibits anti-cancer activity against cancer cell lines and xenografts that do not express EWSR1-FLI1.
| M.Wt | 376.233 | |
| Formula | C19H15Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one |
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1, Filippo Spriano, et al. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
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