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Chemical Structure : TLSC702
Catalog No.: PC-63307Not For Human Use, Lab Use Only.
TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM.
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TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM.
TLSC702 inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner.
TLSC702 more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.
| M.Wt | 325.382 | |
| Formula | C18H15NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42.
2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73.
3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7.
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