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Chemical Structure : TMDJ-035
Catalog No.: PC-21312Not For Human Use, Lab Use Only.
TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.
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TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.
TMDJ-035 (30-100 nM) is effective in preventing generation of Ca2+ waves in cardiomyocytes without affecting action potential-induced Ca2+ transients.
TMDJ-035 is a promising candidate for drug development to treat potentially fatal RyR2-related cardiac arrhythmias.
| M.Wt | 347.30 | |
| Formula | C16H12F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ishida R, et al. Eur J Med Chem. 2023 Oct 25;262:115910.
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