Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TMP-153
Catalog No.: PC-63363Not For Human Use, Lab Use Only.
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.
Hypercholesterolemia
Discontinued
| M.Wt | 437.9 | |
| Formula | C24H18ClF2N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.
2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.
3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
