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Chemical Structure : TMPRSS6 inhibitor 8
Catalog No.: PC-73085Not For Human Use, Lab Use Only.
TMPRSS6 inhibitor 8 (TMPRSS6-IN-8) is a highly potent (IC50=8.1 nM), peptidomimetic inhibitor of TMPRSS6 (matriptase-2).
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TMPRSS6 inhibitor 8 (TMPRSS6-IN-8) is a highly potent (IC50=8.1 nM), peptidomimetic inhibitor of TMPRSS6 (matriptase-2).
TMPRSS6-IN-8 inhibits two closely related TTSPs (matriptase and hepsin, IC50 52 nM and 16 nM, respectively), weakly inhibits thrombin and factor Xa and has no inhibitory activity toward furin.
TMPRSS6-IN-8 forms a reversible covalent bond with TMPRSS6.
Inhibiting TMPRSS6 proteolytic activity prevents cleavage of hemojuvelin (HJV) in HeLa cells (IC50=267 nM).
TMPRSS6 inhibition increases hepcidin encoding gene (HAMP) expression in HepG2 cells and human primary hepatocytes.
| M.Wt | 676.855 | |
| Formula | C33H40N8O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Béliveau F, et al. Cell Chem Biol. 2019 Nov 21;26(11):1559-1572.e9.
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