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Chemical Structure : TN1
CAS No.: 289479-94-3
Catalog No.: PC-42268Not For Human Use, Lab Use Only.
A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM; At 100 nM, increases γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50–100 uM hydroxyurea; a useful starting point for the generation of compounds that can be used for the treatment of SCD.
| M.Wt | 509.6021 | |
| Formula | C29H31N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propynamide, N-[3-[[9-ethyl-2-[(trans-4-hydroxycyclohexyl)amino]-9H-purin-6-yl]amino]phenyl]-3-(4-methylphenyl)- |
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1. Nam TG, et al. ChemMedChem. 2011 May 2;6(5):777-80.
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